A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity
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منابع مشابه
A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity
The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L.) enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated the anti-inflammatory activity, cytotoxic effect and the underlying mechanism of a novel chemicall...
متن کاملTopically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats.
Aqueous extract of C. longa when administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade and aqueous humor (AH) protein level compared to vehicle treated group. Although, prednisolone group showed significantly lower clinical grade, histopathologica...
متن کاملCurcuma longa
Description Curcuma longa, a perennial herb and member of the Zingiberaceae (ginger) family, grows to a height of three to five feet and is cultivated extensively in Asia, India, China, and other countries with a tropical climate. It has oblong, pointed leaves and funnel-shaped yellow flowers.1 The rhizome, the portion of the plant used medicinally, is usually boiled, cleaned, and dried, yieldi...
متن کاملEvaluation of Skin Colouring Properties of Curcuma Longa Extract
The aim of this study was to evaluate the skin colouring properties of curcuma extract in cosmetic formulations. Objective measurements of the skin colour changes were done by Chromameter using the CIE L*a*b* colour space parameters. These measurements were correlated with the results of the sensory analysis. The observations showed permanent, visible and statistically significant changing of b...
متن کاملExtract of Curcuma longa in the treatment of radiation lesions
Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2016
ISSN: 1663-9812
DOI: 10.3389/fphar.2016.00223